What to Do After a Negative Genetic Test
Genetic test came back negative but still sick? Here's why that happens and what steps to take next.
Why Genetic Tests Come Back Negative
The test wasn't comprehensive enough (panel vs. WGS). The variant is in a non-coding region that WES misses. The variant type is hard to detect. The gene hasn't been linked to disease yet. The variant is classified as a VUS (variant of uncertain significance).
What to Do Next
Find out exactly what was tested. Consider broader testing if only a panel or exome was done. Request reanalysis of existing data with updated databases. See a medical geneticist. Explore research programs like the NIH UDN. Don't interpret negative as final: genetic science advances rapidly, and today's VUS may be tomorrow's diagnosis.
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Take the free screening ›This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making medical decisions.