Gene Panels vs. Whole Exome vs. Whole Genome: Which Test Do You Need?
Confused about genetic tests? We compare gene panels, WES, and WGS to help you pick the right one.
The Comparison
Gene panels test 10-500 genes for $250-$1,000. Fast, inexpensive, but requires a hypothesis and misses everything not on the list.
Whole exome sequencing covers ~20,000 genes (coding only) for $500-$1,500. Broad but misses 98-99% of the genome. Diagnostic yield: 25-40%.
Whole genome sequencing reads the entire genome for $900-$3,000. Captures everything including non-coding variants, structural variants, and mitochondrial DNA. About 1 in 5 patients negative on WES get diagnosed with WGS.
How to Decide
Strong suspicion of specific condition: panel first. Unclear diagnosis or negative panel: WES or WGS. Negative WES with persistent symptoms: WGS. Want to do it once and do it right: WGS.
You've waited long enough for answers
Take our free 2-minute screening to see if genetic testing could help.
Take the free screening ›This article is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making medical decisions.